However, MCS has now demonstrated structural/functional benefits in several AD-relevant models, namely Tg2576 (this report), APP/PS1 (Alldred et al., 2021; Dave et al., 2023), Ts65Dn (Velazquez et al., 2013; Powers et al., 2016; Strupp et al., 2016; Powers et al., 2017; Alldred et al., 2021; Alldred et al., 2023), and 3xFAD mice (Dave et al., 2023). Here, APP is linked to Alzheimer disease.