Remarkably, this flavonoid class plays a pivotal role in exhibiting promising biological effects towards tumour hallmarks such as proliferation4, stemness4, inflammation3,4,37 angiogenesis4,37, metastasis4, invasion4, regulation of tumour epigenetics35,36, cell cycle arrest and apoptosis37, inhibition of multidrug resistance proteins37,38 as well as potent inhibitory activity towards VEGFR-2.39 Here, KDR is linked to neoplasm.