Although at the kidney bulk RNA-seq level, we did not detect a significant sex difference in Edn3 (P=0.11), in a mouse hypertensive model (Schlager BPH/2J) and their normotensive control (BPN/3J), females had a 1.7- to 1.9-fold increase in kidney Edn3 [67]. Here, EDN3 is linked to benign prostatic hyperplasia.