IL1B and Alzheimer disease: In Il-17a-deficient AD mice, depletion of intestinal bacteria did not modulate the transcription of Tnf-α, Il-1β, Ccl-2, Il-10, and Mrc-1 (Figure 4, f, h, j, k and m; t test, p > 0.05), except decreasing the transcription of Chi3l3 (Figure 4, l; t test, p < 0.05).