Hypermethylated sites with significant methylation difference (p<1.0x10–10) in these regions were annotated to the long-noncoding RNAs (lncRNAs) LOC107984012 and LOC105373526, ribosomal RNA5S6 and RNA5S5, the genes ATG16L2, GRB10, CLUAP1 and C16orf90, and the pseudogene MRPS11P1. Only GRB10 has been previously associated with diabetes-related complications. The gene discussed is GRB10; the disease is diabetes mellitus.