Therefore, investigating the balance of copper metabolism in diabetes regulation offers a novel direction for understanding the mechanisms underlying diabetes.Consequently, based on the groundbreaking discoveries regarding cuproptosis by the research team led by Tsvetkov P (3), genes including LIAS, FDX1, LIPT1, DLD, DLAT, PDHA1, PDHB, MTF1, GLS, CDKN2A, SLC31A1, ATP7A, and ATP7B, along with the associated proteins Glutathione and HSP70 mentioned in this article related to cuproptosis, were gathered. Here, DLD is linked to diabetes mellitus.