METTL3 and Chronic tubulointerstitial nephritis: In contrast, substantial expression of METTL3 was evident in kidney biopsies from patients with different CKDs, including membranous nephropathy (MN), focal and segmental glomerulosclerosis (FSGS), chronic tubulointerstitial nephritis (CTIN), IgA nephropathy (IgAN), diabetic kidney disease (DKD) and lupus nephritis (LN) (Figure 2A).