As shown in Figure 2H, METTL3 was co-expressed with Lotus tetragonolobus lectin (LTL) (proximal tubule marker), Peanut agglutinin (PNA) (distal tubule marker) and Dolichos biflorus agglutinin (DBA) (collecting duct marker) in the kidney of CKD patients, suggesting that METTL3 is expressed in the major segments of kidney tubules in CKD. This evidence concerns the gene METTL3 and chronic kidney disease.