In contrast, Tsui et al. demonstrated that MT3 overexpression promoted the proliferation, invasion and tumorigenesis of bladder cancer cells by downregulating the expression of N-myc downregulated gene 1 (NDRG1), NDRG2, and mammary serine protease inhibitor (MASPIN) gene 22. This evidence concerns the gene NDRG2 and urinary bladder carcinoma.