Consistently, in the second period (2.5-year) study, we found 45.5% and 24.5% lymphoma incidence in Nlp-/- and Nlp+/- mice respectively, while only 4.2% Nlp+/+ mice were prone to lymphoma (p value were 0.0014 and 0.0486). The gene discussed is NINL; the disease is lymphoma.