Several HDAC members, including HDAC1, HDAC2, HDAC4, HDAC7, etc., have been reported to correlated with HCC progression and patient survival 49, and HDAC2 expression is upregulated in Lenvatinib-resistant cells 50, suggesting a potential role of HDACs in Lenvatinib resistance. The gene discussed is HDAC2; the disease is hepatocellular carcinoma.