PIK3CA and neoplasm: Oncogenic activation of the PI3K/Akt cascade leads to a wide metabolic reprogramming via upregulation of glucose transporters and glycolytic enzymes, also impacting on pentose phosphate pathway (PPP), mitochondrial oxidative phosphorylation, de novo lipid synthesis and redox homeostasis and thus fulfilling both the catabolic and anabolic needs of tumor cells 2.