A further characterization of HK2 functions in tumors has been recently provided by Ciscato et al., who have demonstrated that 80% of this protein lodges in mitochondria-associated membranes (MAMs), small subcellular regions connecting the OMM to the endoplasmic reticulum (ER); there, it can participate to the IP3R-GRP75-VDAC1-mediated control of Ca2+ homeostasis, contributing to the proliferation of cancer cells 36. This evidence concerns the gene HK2 and cancer.