SETD7 and nonpapillary renal cell carcinoma: Then in order to examine the role of SETD7 in ccRCC cell progression, we designed and synthesized two small interfering RNAs (siRNAs) that silenced the expression of SETD7, qRT-PCR and western blotting were performed to detect the knockdown efficiency of siRNAs and as shown in Fig. 1D and Fig. S1B, the mRNA and protein expression of SETD7 was successfully inhibited.