KRT14 and Alzheimer disease: To further elucidate the role and mechanisms of IL-38 in AD, we generated IL-38f/f mice through transgenic insertion of the Floxp site, and obtained IL-38 keratinocyte-specific knockout mice (K14Cre/+-IL-38f/f) by crossing with K14-promoter Cre (Krt14-Cre) transgenic mice (Figure S2A-C), as we previously reported 22.