IGHE and Alzheimer disease: The AD model showed a significant increase in Th2 and Th1 cells in the lymph nodes (Figure S1C), elevated expression of IL-4, IFN-γ, TSLP cytokines in the lesions (Figure S1D), and increased serum IgE levels (Figure S1E), consistent with previous findings 34, indicating the successfully construction of the DNFB-induced AD model.