CPEB1 tends to play a tumor suppressive role in cancer: it is commonly low-expressed in solid tumors through DNA hypermethylation 10, 11; moreover, it inhibits tumor growth and metastasis, and attenuates stemness in multiple cancer types including breast cancer 12, glioblastoma 13, gastric cancer 10, colorectal cancer 11 and hepatic cancer 14. This evidence concerns the gene CPEB1 and neoplasm.