CPEB1 and colorectal cancer: CPEB1 tends to play a tumor suppressive role in cancer: it is commonly low-expressed in solid tumors through DNA hypermethylation 10, 11; moreover, it inhibits tumor growth and metastasis, and attenuates stemness in multiple cancer types including breast cancer 12, glioblastoma 13, gastric cancer 10, colorectal cancer 11 and hepatic cancer 14.