CPE and cancer: Despite having similar functional domains and RNA affinities for targeting the CPE sequence in the 3'-UTR of mRNA to facilitate or inhibit translation 7, 36, the oncological significance of CPEB1 and CPEB4 is completely opposite: CPEB4 promotes tumor proliferation, migration, invasion, and vascularization 36, 37, whereas CPEB1 inhibits cancer progression as a tumor suppressor 14, 38.