In an in vitro model employing OSCC cells and an in vivo xenograft model of oral cancer, an NLRP3 inflammasome inhibitor BAY-117082 significantly reduced NLRP3, ASC, caspase-1, IL-1β, and IL-18 expression and a reduction in tumor growth 50. The gene discussed is CASP1; the disease is lip and oral cavity carcinoma.