Cinnamaldehyde mediates endoplasmic network stress and cellular autophagic death through the PRKR-like endoplasmic reticulum kinase/C/EBP homologous protein (PERK/CHOP) signaling pathway, inhibition of G9a binding to beclin 1 (BECN1) and light chain 3B (LC3B) promoters, and dissociation of BCL2/BECN1 in gastric cancer cells. The gene discussed is BECN1; the disease is gastric cancer.