MFSD12 and melanoma: Although studies have shown that MFSD12 stimulates cell cycle progression in melanoma, leading to increased cell proliferation (Wei et al., 2019), however, Bhardwaj et al. found that knockdown of MFSD12 leads to increased levels of basal lysosomal lipid peroxidation (LLP) in melanoma cells, leading to lysosomal membrane penetration (LMP) and mediating cell death (Bhardwaj et al., 2023), suggesting that cysteine entry into lysosomes via MFSD12 is required to rescue LLP, LMP, and lysosomal cell death.