Basiorka et al. reported activation of the NLRP3 inflammasome in hematopoietic stem and progenitor cells as a critical convergence signal in myelodysplastic syndromes (MDS), which direct activation of NLRP3 complexes and CASP1 and generation of IL-1β and pyroptotic cell death 27. The gene discussed is NLRP3; the disease is myelodysplastic syndrome.