We found decreased generation of ROS and activity of MMP by glutamine in AngII-treated mouse abdominal aortic tissue, meaning that glutamine is effective in attenuating apoptosis of VSMC, inhibiting secretion of inflammatory factors, and maintaining normal structure of aorta, as excessive production of ROS and activity of MMP have been reported to be detrimental factors exacerbating VSMC apoptosis, promoting macrophage polarization, and finally causing the formation and progression of AAA 17,30. The gene discussed is AGT; the disease is triple-A syndrome.