IRS1 and type 2 diabetes mellitus: Similarly, the expression of c-miR-126 has also been shown to be altered with exercise (Barber et al., 2019; Eyileten et al., 2021) and concomitantly a potential biomarker for type-2 diabetes due to its interference with insulin signaling by targeting IRS1 and IRS2, resulting in insulin resistance (Nigi et al., 2018).