More specifically, a quantitative 18F-flortaucipir PET study conducted on individuals with cognitive impairment revealed that the dosage of the ApoE-ε4 gene had a sex-specific effect on tau deposition in regions like the amygdala, medial temporal lobe, lateral temporal lobe, posterior cingulate cortex, entorhinal cortex, parahippocampal gyrus, and inferior temporal regions (Yan et al., 2021). The gene discussed is APOE; the disease is Cognitive impairment.