Notably, the accumulation of phosphorylated tau in the entorhinal cortex occurs more rapidly and to a greater extent in women than in men, contributing to the elevated susceptibility of women to AD compared with that of men (Hu et al., 2021; Chen X. L. et al., 2023), which indicates that the mechanisms that contribute to the entorhinal cortex’s notable susceptibility to AD could be closely connected to those responsible for the sex differences in AD pathogenesis. This evidence concerns the gene MAPT and Alzheimer disease.