Furthermore, AD is biologically defined by specific neuropathological features (Jack et al., 2018), including extracellular accumulation of β-amyloid (Aβ) in diffuse and neuritic plaque forms alongside the existence of intraneuronal neuropil threads and neurofibrillary tangles within dystrophic neurites consisting of polymerized hyperphosphorylated tau protein (Long and Holtzman, 2019). This evidence concerns the gene MAPT and Alzheimer disease.