Additionally, there exist a multitude of significant genes that vary between sexes and are linked to depression, like ORM1, ORM2, RNF32, SLC25A5, Thbs1, and Cadps2 etc., manifesting sex-specific impacts on depression risk (Miyata et al., 2020; Paden et al., 2020). This evidence concerns the gene THBS1 and depressive disorder.