The most characteristic pathological changes in AD are the accumulation of neuroinflammatory extracellular β-amyloid (Aβ) deposits and intracellular hyperphosphorylated tau protein neurofibrillary tangles (NFT) (Serrano-Pozo et al., 2011; Reitz and Mayeux, 2014). Here, MAPT is linked to Alzheimer disease.