A recent study reported that in an APP/PS1/Cx3cr1 AD mouse model, patrolling monocytes could climb up the lumen wall of Aβ-positive veins and target Aβ clearance from the venous lumen, as observed by in-vivo two-photon microscopy (Michaud et al., 2013). This evidence concerns the gene CX3CR1 and Alzheimer disease.