Replicated MR analysis between Cathepsin B and PD showed a similar effect in the FinnGen consortium (OR = 0.921, 95% CI = 0.860–0.987, p = 0.020 for the IVW method) (Table 2) and remained significant in the combined meta-analysis (OR = 0.905, 95% CI = 0.862–0.951, p < 0.0001) (Figure 5). This evidence concerns the gene CTSB and Parkinson disease.