The up- or downregulation of additional genes that showed sex-specific responses (G0s2, Igfbp1, Mfsd2a, Myc, and Tat), as observed in the male rats, has been reported to increase lipid accumulation and lead to a non-alcoholic steatohepatitis-like phenotype (Fu et al., 2010; Wang et al., 2013; de la Garza et al., 2017; Jiang et al., 2021; Chin et al., 2023). This evidence concerns the gene G0S2 and metabolic dysfunction-associated steatohepatitis.