Figures 4C,D display the ROC curves corresponding to upregulated and downregulated genes separately. The AUC percentage for BGN, COL1A1, VCAN, FN1, COL6A3, COL4A5, and FBLN1 were 93, 95, 82, 70, 74, 82, and 76%, respectively. The survival analysis of the hub genes detected (COL4A5, FN1, FBLN1, and VCAN) could predict the prognosis of GC (Figures 4E–K). This evidence concerns the gene COL1A1 and gastric cancer.