TLR4 and hyperinsulinemic hypoglycemia, familial, 4: Interestingly, Toll and Immune deficiency (Imd) pathways are not required for expression of the dengue virus-blocking phenotype in the Drosophila host and Wolbachia endosymbionts do not interact with the Toll pathway-mediated resistance to viral oral infection (Rancès et al., 2013; Ferreira et al., 2014).