CELSR3 and cloacal exstrophy: Interestingly, Reutter et al. identified a patient with cloacal exstrophy, a subtype of BEEC, who was a compound heterozygote for two CELSR3 coding variants [c.5470G>A (p.Val1824Met) and c.6950T>C (p.Met2317Tyr)] (Reutter et al., 2016).