High-grade B-cell lymphoma with MYC and BCL2 rearrangements was detected in 9% of all large B-cell lymphoma specimens, including one case with rearrangements at all three loci MYC, BCL2, and BCL6; MYC and BCL6 rearrangements were found in 1.6% of specimens. Here, BCL2 is linked to B-cell non-Hodgkin lymphoma.