An important subset of diffuse large B-cell lymphoma (DLBCL) and high-grade B-cell lymphoma (HGBCL) have MYC and BCL2 rearrangements Large B-cell lymphoma or high-grade B-cell lymphoma with MYC and BCL2 rearrangements are commonly referred to as "double-hit" lymphoma (DHL), which portends more aggressive clinical behavior and inferior progression-free survival compared to other cases of diffuse large B-cell lymphoma, germinal center B-cell subtype, or other high-grade B-cell lymphoma (1–5). The gene discussed is BCL2; the disease is lymphoma.