Both the 5th Edition of the World Health Organization Classification of Haematolymphoid tumors (WHO5) (6) and the International Consensus Classification of Lymphoid Neoplasms (ICC) (7) now classify diffuse large B-cell lymphoma and high-grade B-cell lymphoma with concurrent MYC and BCL6 “double-hit” lymphomas separately due to the unclear prognostic significance of this combination, with some studies not showing distinct biology for these cases (1, 2), but other studies demonstrating an association with a poor outcome (3, 8–11). This evidence concerns the gene BCL6 and B-cell non-Hodgkin lymphoma.