Concurrent MYC and BCL2 rearrangements were detected in 20 of the 197 specimens (10%) that had FISH successfully performed at both MYC and BCL2 loci; for 19 of these 20 specimens, this result established the diagnosis as high-grade B-cell lymphoma with MYC and BCL2 rearrangements (high-grade B-cell lymphoma-MYC/BCL2). Here, BCL2 is linked to B-cell non-Hodgkin lymphoma.