Dose-limiting: thrombocytopenia (persistent grade 1); ↑ ALT (grade 3); and azotemia in 3.4% each. Non-dose-limiting: ↑ ALP (grade 1 to 3) in 17.2%; ↑ ALT (grade 1 to 2) in 6.9%; and transient grade 1 thrombocytopenia and diarrhoea in 3.4% each. The gene discussed is GPT; the disease is Thrombocytopenia.