Preeclampsia is the main cause of high maternal and fetal morbidity and mortality in humans, and there is higher endogenous activation of NLRP1/NLRP3 inflammasomes and protein expression of IL-1β, IL-18, and tumor necrosis factor-α in the peripheral blood monocytes of preeclamptic pregnant women compared to normal controls (42). This evidence concerns the gene IL18 and preeclampsia.