For example, data suggest the VPS13A involvement in the protein degradation machinery and autophagy in ChAc pathophysiology (Muñoz-Braceras et al., 2015; Lupo et al., 2016; Vonk et al., 2017), a process that is also altered in HD (Ravikumar et al., 2004). The gene discussed is VPS13A; the disease is chorea-acanthocytosis.