For instance, the mutations in genes such as PIK3CA (phosphatidylinositol‐4,5‐bisphosphate 3‐kinase catalytic subunit alpha) and AKT1 (AKT serine/threonine kinase 1) can lead to dysregulation of the pathway or alteration of signaling capacity, resulting in the development of insulin resistance and its association with T2DM.37, 38. The gene discussed is AKT1; the disease is type 2 diabetes mellitus.