NRP1 is associated with increased matrix stiffness by promoting fibronectin reorganization and collagen secretion (Cao et al., 2010; Yaqoob et al., 2012), mediated by its role as a coreceptor for β1 integrins (Valdembri et al., 2009) and TGF-β1 (Glinka et al., 2011); the last one a relevant growth factor for myofibroblasts recruitment and tumor fibrotic response (Cao et al., 2010; Kojima et al., 2010; Papageorgis and Stylianopoulos, 2015). Here, NRP1 is linked to neoplasm.