SOCE is the major influx of Ca2+ in non-excitable cells (Zhou et al., 2017), however, high expression of STIM1, ORAI1, and activated SOCE were found to be involved in cancer progression, migration, and metastasis for cervical cancer (Chen et al., 2011; Chen et al., 2013), breast cancer (Yang et al., 2009) and hepatocarcinoma (Yang et al., 2013). Here, ORAI1 is linked to cancer.