Given that burn-related injuries can lead to mortalities through infection, fluid loss, and pH imbalances, leading to organ failure, the relevance of the transgenic LGR5+ pig model becomes even more significant, particularly considering the roles of LGR5+ cells in microbial responses and regeneration (Sigal et al., 2017; Huch et al., 2015; Lin et al., 2017). This evidence concerns the gene LGR5 and infection.