CD8A and colorectal carcinoma: In CRC and CM, apCAFs are significantly positively correlated with exhausted CD8+ T cells, akin to findings in CRC where CAFs driven antigen cross-presentation via MHC class I molecules led to CD8+ T cells exhaustion (57), and in a B16 cell model where CAFs mediated antigen cross-presentation via MHC class I molecules weaken CD8+ T cells cytotoxic effects (58).