Similarly, in 7 other cohorts like GSE102349-NPC, TCGA-CESC, TCGA-COAD, TCGA-READ, TCGA-BRCA, TCGA-SKCM, and TCGA-KIRC, we consistently showed a robust positive relationship between apCAFs gene signature scores and CD4+ effector T cells gene signature scores (Supplementary Figures 7O-U). Here, CD4 is linked to nasopharyngeal carcinoma.