In our findings, we noted the enrichment of TFs such as OTUD4, RUNX3, and IKZF1 in HNSCC (Figure 6A), STAT4, RUNX3, and IKZF1 in OV (Figure 6B), IKZF1, KLF3, and RUNX3 in NPC (Figure 6C), IKZF1, RUNX3, and SPI1 in BRCA (Figure 6D), IKZF1, RUNX3, and BCL11B in CM (Figure 6E), and IKZF1, TCF7, and RUNX3 in RCC (Figure 6F). Here, SPI1 is linked to renal cell carcinoma.