CD4 and colorectal carcinoma: However, in CC scRNA-seq data cohort, there is a significant negative correlation between apCAFs gene signature scores and CD4+ effector T cells gene signature scores (Supplementary Figure 8F), while in CRC scRNA-seq data cohort, there is no significant correlation between apCAFs gene signature scores and CD4+ effector T cells gene signature scores (Supplementary Figure 8G).