AKT1 and bladder transitional cell carcinoma: KEGG pathway enrichment analysis indicated that the DEGs upregulated in the fibroblasts of UTUC were enriched in the PI3K-Akt signaling pathway, ECM-receptor interaction, and leukocyte transendothelial migration (Figure 10B), whereas the DEGs upregulated in the fibroblasts of BLCA were enriched in antigen processing and presentation, ribosome, and endocytosis (Figure 10C).