Fujii and their team analyzed the pairwise relationships between mutations and copy number alterations in 188 non-hypermutated UTUC samples, revealing four distinct subtypes with unique co-alteration/mutually exclusive patterns characterized by the presence/absence of alterations in TP53 or MDM2, RAS, and FGFR3, further indicating that the detections of such common mutation sites using urinary sediment sequencing has potential value as both a prognostic biomarker and a diagnostic tool in UTUC (92). Here, TP53 is linked to renal pelvis/ureter urothelial carcinoma.