In order to substantiate that the detected differences in Lck and Akt activities in SpnWT-infected vs. SpnΔlctOΔspxB-infected H441 cells are predominantly due to pneumococcal H2O2 (Figures 5, 7), we performed infection experiments in the presence of exogenously added H2O2 (1 mM) in cells infected with SpnΔlctOΔspxB. Here, LCK is linked to infection.