Mechanistically, F. nucleatum induces PD-L1 expression through activation of the STING signaling pathway, leading to increased accumulation of IFN-γ+CD8+ tumor-infiltrating lymphocytes (TILs) during PD-L1 blockade therapy, thus enhancing tumor sensitivity to PD-L1 blockade. The gene discussed is STING1; the disease is neoplasm.