MAVS-disrupted clones 5 and 20 both gave a significant increase in virus titers for SAV-3, with less effect for clone 5 with a lower proportion of disrupted alleles, i.e., 0.8 log10 (p<0.05) TCID50/mL increase in virus titers for clone 5 and 1.5 log10 (p<0.001) for clone 20, compared to CHSEWT 10 days post-infection (Figure 3A). The gene discussed is MAVS; the disease is infection.