Other mechanisms that may lead to constitutive PD-L1 expression in tumor cells include PI3K/AKT mutations, PTEN deletions, EGFR mutations, ALK rearrangements, MYC overexpression, CDK4/CDK6 disruption, and an increase in PD-L1 transcripts stabilized by truncation of the 3’ UTR of the gene (36–42). Here, CD274 is linked to neoplasm.