Inhibits T-cell proliferation, cytotoxic activity and promotes metastasisDiminish the clonal expansion of T lymphocytesLeads to a Th17 phenotype associated with an inhibition of the anti-tumoral immune responseInhibits the maturation and migration of dendritic cells (DCs)Decrease in ROS productionImpair the anti-tumor activity of CD8+ T cellsBoost the immunosuppressive cell populations such as MDSCs, TAM, Th2 CD4+ T cells and Tregs. This evidence concerns the gene CD4 and neoplasm.