Although levels of anti-Hsp autoantibodies are elevated in patients suffering from numerous inflammatory and autoimmune diseases, including rheumatoid arthritis (RA) (37–40), juvenile idiopathic arthritis (41), autoimmune myasthenia gravis (42), dermatitis herpetiformis (DH) (43), psoriasis (44), systemic lupus erythematosus (SLE) (45), epidermolysis bullosa acquisita (EBA) (46), celiac disease (CD) (47), atopic dermatitis (48) and other (auto)inflammatory diseases, their pathological role is not fully understood (Table 1). Here, HSP90B2P is linked to autoimmune disease.