AA, amino acids; Bromo_SNF2L2, Bromodomain, SNF2L2-like subfamily; CDS, coding sequence; DEXDc, DEXH-box helicase domain; COSMIC, Catalog of Somatic Mutations in Cancer; HELICc, helicase c; QLQ, pfam08880; SNF2_N, SNF2 family N-terminal domain. The gene discussed is SMARCA4; the disease is cancer.