From the liver explant, the CTNNB1 K335I finding in the region of the 11.5 cm adenoma containing hepatocellular carcinoma explant confirms the presence of an activating mutation of the β-catenin gene. CTNNB1 is the most frequently mutated gene in hepatocellular carcinoma [46]. This evidence concerns the gene CTNNB1 and hepatocellular carcinoma.