In contrast, γδ T-APCs generated in the presence of the cytokine IL-21 (γδIL-21 T-APCs), which is closely related to IL-2 and IL-15 and overproduced in active IBD [25], induced lower levels of CD4+ T-cell proliferation and lower expression of IFN-γ and IL-22 [24]. This evidence concerns the gene IL21 and inflammatory bowel disease.