ANXA5 and cancer: In order to understand the efficiency of ExoDS compared with the unconjugated form of doxorubicin in inducing apoptosis in cancer cells (Figure 3C) and cancer stem cells (Figure 3D) derived from MCF-7, MDA-MB-468, and MDA-MB-231 cells, we performed an apoptosis assay using Annexin V. Our analysis showed that ExoDS (5 ng/mL) induced almost comparable killing compared to the unconjugated form of doxorubicin (1.8 μg/mL) at an almost 400-fold lower concentration in MCF-7, MDA-MB-468, and MDA-MB-231-derived cancer cells and cancer stem cells.