EDN1 and neoplasm: On the contrary, using annotations for PTSF (Supplementary Image S5) and SF (data not shown), these parameters correlated with tumor suppressive events including downregulation of cell-cycle promoter Cyclin D1 and angiogenic factor VEGF (8), yet they showed to upregulate HIFβ implicated in tumor hypoxia (35), PKC involved in calcium signaling and cellular contractility (36), and ET1, the aberrant expression of which was shown to promote tumorigenesis (37).