Importantly, ASPM expression was upregulated both at the mRNA and protein levels in liver cancer tissue, enhanced HCC cell proliferation and Epithelial-to-Mesenchymal Transition (EMT), as well as stimulated the Wnt––β‐catenin signaling by antagonizing the disheveled‐2 (Dvl2) degradation mediated by autophagy (Zhang et al., 2021). The gene discussed is DVL2; the disease is hepatocellular carcinoma.