TCGA database was screened for RBPs differentially expressed in tumors versus normal samples, and a set of 7 RBPs (CLK1, DDX39A, EEF2, ELAC1, NKRF, POP7 and SMN1), most of which were related to overall survival of ESCC individuals, were obtained as prognostic model. Here, POP7 is linked to esophageal squamous cell carcinoma.