In particular, over-expression of the RBP, Epithelial Splicing Regulatory protein 1 (ESRP1), which are the “splicing masterminds” of epithelial cells, led to the surge of a partial Epithelial-to-mesenchymal transition (EMT) status in CRC cells, as happens with the downregulation of its expression, seemingly through the context-dependent association of this RBP with different RNPs (Fagoonee et al., 2017; Ala et al., 2020; Manco et al., 2021; Advani et al., 2023). Here, ESRP1 is linked to colorectal carcinoma.