The comparison of the expression of these modulated RBPs with those of CHOL TCGA highlighted 4 differentially expressed transcripts in both PSC and CHOL versus normal conditions, also characterized by similar expression pattern in the different comparisons: Assembly factor for spindle microtubules (ASPM) and Piwi Like RNA-Mediated Gene Silencing 4 (PIWIL4) upregulated in serum and Fanconi anemia complementation group D2 (FANCD2) upregulated in urine and Zinc finger protein 582 (ZNF582) downregulated in urine (Table 4; Table 5). The gene discussed is PIWIL4; the disease is anemia (phenotype).