Melanoma and Breast cancer mouse models show that circadian rhythm disturbance enhances cancer cell proliferation, stemness, spread and metastasis, induces immunosuppressive TME by increasing the proportion of TAM and regulatory T cells (TREGs), and promotes the differentiation of macrophages into anti-inflammatory phenotype, resulting in reduced infiltration of active CD8+ T cells (Aiello et al., 2020; Hadadi et al., 2020). The gene discussed is CD8A; the disease is melanoma.