WARS1 and PILRA were identified in the SMR analysis of both protein datasets for AMD, with WARS1 showing a consistent risk trend but PILRA showing a different direction, thus PILRA was excluded; for Dry-AMD, the analysis of the two protein datasets for WARS1 and ACADSB showed the same trend; for Wet-AMD, WARS1 showed the same trend in the analysis of both protein datasets. The gene discussed is WARS1; the disease is age-related macular degeneration.