The protective effect of SFTA2 was validated in the replicated data for AMD (Supplementary Table S5); SFTA2, LTA, HSPA1L, and ACADSB were identified as protective proteins for Dry-AMD, with COL10A1 and WARS1 as the risk proteins; for Wet-AMD, SFTA2, VARS1, and HSPA1L were identified as protective proteins, while COL10A1, WARS1, VTN, SDF2, and LBP were identified as risk proteins. Here, SDF2 is linked to age-related macular degeneration.