Specifically, the protective effect of TNFRSF10A on AMD was validated in the replicated data (Supplementary Table S9); PAXX and ACADSB were identified as protective proteins for Dry-AMD, while IL20RB, WARS1, and DPEP2 were identified as risk proteins; for Wet-AMD, CD226, TGFB1, and TNFRSF10A were identified as protective proteins, while CSF2, ABO, and WARS1 were identified as risk proteins. Here, PAXX is linked to age-related macular degeneration.